When we talk about a bike's drivetrain, common sense dictates that a straight groupset is the gold standard. A straight groupset is where all the components of the drivetrain (cranks, derailleurs, cassette, shifters and brakes) are all from the same series. By having a straight groupset, we can have the smoothest coordination between the different components for an efficient operation.
An example of a straight groupset. Pictured above is a 10-speed Dura-Ace groupset (Special Anniversary Edition).